ABC Transporters and Multidrug Resistance (Wiley Series in by Ahcene Boumendjel, Jean Boutonnat, Jacques Robert

By Ahcene Boumendjel, Jean Boutonnat, Jacques Robert

A accomplished evaluate of the most up-tp-date medical study on ABC transporters and multidrug resistanceATP-binding cassette transporter genes (ABC transporters) are identified to play an important function within the improvement of multidrug resistance (MDR). MDR is the power of pathologic cells, akin to tumors, to resist chemical compounds designed to focus on and break such cells. In MDR, sufferers who're on drugs ultimately advance resistance not to simply the drug they're taking, yet to numerous sorts of drugs.ABC Transporters and Multidrug Resistance deals an important source for pharmaceutical researchers who're operating to find medications to counteract multidrug resistance in ailments resembling melanoma. in a single finished quantity, this publication incorporates a choice of the most up-tp-date wisdom at the involvement of ABC transporters in drug delivery and resistance.This finished quantity presents an summary at the description of the constitution, the genome, general tissue expression, physiological point, and mechanism of motion of the ABC protein. The specialist participants discover the expression, detection, and implications of ABC proteins in hematological malignancies and strong tumors and ABC proteins and pathogenic microorganisms. This quantity additionally explains MDR modulation via inhibition of ABC transporters and the layout of inhibitors and mechanism of motion. additionally, the ebook bargains crucial info at the organic and medical point of multidrug resistance.

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Extra resources for ABC Transporters and Multidrug Resistance (Wiley Series in Drug Discovery and Development)

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2006. Preferential expression of a high number of ATP binding cassette transporters in both normal and leukemic CD34 + CD38- cells. Leukemia 20: 750–754. 103. Chaudhary PM and Roninson IB. 1991. Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells. Cell 66: 85–94. 104. Dean M, Fojo T, and Bates S. 2005. Tumour stem cells and drug resistance. Nat Rev Cancer 5: 275–284.

99. Doran A, Obach RS, Smith BJ, Hosea NA, Becker S, Callegari E et al. 2005. The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: Evaluation using the MDR1A/1B knockout mouse model. Drug Metab Dispos 33: 165–174. 100. Lin JH and Yamazaki M. 2003. Clinical relevance of P-glycoprotein in drug therapy. Drug Metab Rev 35: 417–454. 101. Keshet GI, Goldstein I, Itzhaki O, Cesarkas K, Shenhav L, Yakirevitch A et al. 2008. MDR1 expression identifies human melanoma stem cells.

Recently, Greer and Ivey (88) have described several possible N-glycanic structures of overexpressed human P-gp. One of them contains a high-mannose complex oligosaccharide, while two other structures present terminal sialic acids. The α6 sialyl terminal groups and β1–6 branching glycans are highly expressed in cancers due to the regulation of acetylglucosaminyltransferase V, which could include the glycosylation of P-gp (89). 3. 1. Expression in Normal Tissues and Tumors Several normal tissues express high levels of the ABCB1 gene, such as apical membranes of epithelial cells from kidney proximal tubule, intestine, and lung.

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