Abnormalities in Puberty: Scientific and Clinical Advances by H.A. Delemarre-van de Waal, P.-E. Mullis

By H.A. Delemarre-van de Waal, P.-E. Mullis

This publication on abnormalities in puberty offers an outline at the most modern wisdom at the mechanisms of the developmental techniques of puberty. even supposing the precise mechanisms of reawakening of the GnRH pulse generator on the onset of puberty nonetheless must be elucidated, many genetic and environmental components were pointed out to play a tremendous position. issues mentioned in person chapters contain the endocrine and metabolic concerns with regards to the 'developmental starting place of grownup sickness' speculation and polycystic ovary syndrome in addition to abnormalities in GnRH controlling genes, GnRH-secreting hamartoma as a version for the onset of puberty, event at the software of GnRH analogues within the therapy of vital precocious puberty, and the psychosocial results of an early puberty. This quantity offers the paediatrician, endocrinologist, gynaecologist and medical professional with underlying details in addition to functional tokens on how you can deal with some of the stipulations of a disturbed means of puberty.

Show description

Read Online or Download Abnormalities in Puberty: Scientific and Clinical Advances (Endocrine Development, Vol. 8) PDF

Similar endocrinology books

Thyroid Disease in Adults

This booklet is a entire consultant to the evaluation and administration of adults with thyroid issues in day-by-day scientific perform. All very important facets and problems are thought of. appropriate info on uncomplicated anatomy, embryology, immunology, and body structure is incorporated to supply a greater foundation for realizing the advance of ailment and its prognosis and therapy.

Molecular Biology of the Parathyroid (Molecular Biology Intelligence Unit)

Aintaining extracellular calcium concentrations inside a slim diversity is necessary for the survival of so much vertebrates. PTH, including nutrition D, responds to hypocalcemia to extend extracellu­ M lar calcium degrees, by way of performing on bone, kidney and gut. the hot intro­ duction of PTH as an enormous healing agent in osteoporosis has directed renewed curiosity during this very important hormone and within the body structure of the parathyroid gland.

Handbook of Biologically Active Peptides, Second Edition

Guide of Biologically energetic Peptides, moment version, is the definitive, vital reference for peptide researchers, biochemists, cellphone and molecular biologists, neuroscientists, pharmacologists, and endocrinologists. Its chapters are designed to be a resource for employees within the box and permit researchers operating in a selected region to ascertain similar components open air their services.

Hypertension and Stroke: Pathophysiology and Management (Clinical Hypertension and Vascular Diseases)

This well timed quantity addresses the intimate pathophysiologic dating among high blood pressure and heart problems. high blood pressure is among the most vital worldwide public wellbeing and fitness demanding situations, and its dating to stroke and different catastrophic cerebrovascular illnesses is a space of becoming realizing.

Additional resources for Abnormalities in Puberty: Scientific and Clinical Advances (Endocrine Development, Vol. 8)

Sample text

Weissenbruch/Engelbregt/Veening/Delemarre-van de Waal 30 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 Gluckman PD, Harding JE: Fetal growth retardation: Underlying endocrine mechanisms and postnatal consequences. Acta Paediatr Suppl 1997;422:69–72. Gluckman PD, Harding JE: The physiology and pathophysiology of intrauterine growth retardation. Horm Res 1997;48(suppl 1):11–16. Godfrey KM, Barker DJP: Fetal nutrition and adult disease. Am J Clin Nutr 2000;71(suppl): 1344S–52S.

Adrenal androgen secretion rises again from around the age of 6 years onwards at ‘adrenarche’ [62]. Low-birthweight infants have relative hypoplasia of the fetal zone [63], and lower DHEAS levels in both plasma and urine during the first 24 h of life compared with normal birthweight infants [64, 65]. Norman et al. [66] studied 22 twin pregnancies, each with one IUGR twin and one normal birthweight twin. In each pair, the IUGR twin had lower DHEAS levels in umbilical arterial blood at birth than their larger twin, but cortisol levels were no different.

The fetal zone does not express 3␤-HSD (required for cortisol production), but does express P450scc and P450c17 (required to produce DHEAS). This fetal zone rapidly disappears during the first few weeks after birth and DHEA and DHEAS levels are usually undetectable [61, 62]. Adrenal androgen secretion rises again from around the age of 6 years onwards at ‘adrenarche’ [62]. Low-birthweight infants have relative hypoplasia of the fetal zone [63], and lower DHEAS levels in both plasma and urine during the first 24 h of life compared with normal birthweight infants [64, 65].

Download PDF sample

Rated 4.85 of 5 – based on 50 votes