Adrenal Toxicology (Target Organ Toxicology Series) by Philip W. Harvey, David J. Everett, Christopher J. Springall

By Philip W. Harvey, David J. Everett, Christopher J. Springall

Despite being considered as the commonest toxicological aim within the endocrine method, the adrenal gland has frequently been overlooked in regulatory checking out. Adrenal Toxicology addresses the elevated curiosity in adrenocortical toxicology and the necessity for a source that makes recommendations to be had to ascertain adrenal endocrine disruption.

Examining present suggestions and the newest developments, Adrenal Toxicology reports the endocrinology, pharmacology, pathology and toxicology of the adrenal gland. this article offers details at the variety of substances and chemical compounds that have an effect on adrenocortical functionality and indicates standardized ways for in vivo and in vitro evaluate. This quantity additionally offers fresh advancements within the molecular mechanisms of toxicity to the adrenal cortex and medulla, and considers environmental adrenal endocrine disruption in sentinel species.

Adrenal Toxicology:

  • reflects the most important advancements remodeled the prior decade
  • focuses at the most modern learn concepts, together with their makes use of and limitations
  • provides an built-in procedure for adrenal toxicology evaluation
  • identifies wisdom and knowledge gaps, supplying impetus for regulatory consideration

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Extra resources for Adrenal Toxicology (Target Organ Toxicology Series)

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Muller-Vieira U, Angotti M, Hartman RW. The adrenocortical tumor cell line NCI-H295R as an in vitro screening system for the evaluation of CYP11 B2 (aldosterone synthase) and CYP11B1 (steroid-11beta-hydroxylase) inhibitors. J Steroid Biochem Mol Biol 2005; 96:259–270. Munck A, Guyre PM, Holbrook NJ. Physiological functions of glucocorticoids in stress and their relation to pharmacological action. Endocr Rev 1984; 5:25–44. Newell-Price J, Bertagna X, Grossman AB, et al. Cushing’s syndrome. Lancet 2006; 367(9522):1605–1617.

Inhibitory effect of efonidipine on aldosterone synthesis and secretion in human adrenocarcinoma (H295R) cells. J Cardiovasc Pharmacol 2006; 47:133–138. Janossy A, Saez JM, Li JY. Carbachol induces homologus steroidogenic refractoriness of bovine fasciculata-reticularis cells. Mol Cell Endocrinol 2001; 172:147– 155. Adrenal Toxicology 29 Johansson MK, Sanderson JT, Lund BO. Effects of 3-MeSO2-DDE and some CYP inhibitors on glucocorticoid steroidogenesis in the H295R human adrenocortical carcinoma cell line.

Biochem Pharmacol 2007; 73:873–879. Letcher RJ, Sanderson JT, Bokkers A, et al. Effects of bisphenol A-related diphenylalkanes on vitellogenin production in male carp (Cyprinus carpio) hepatocytes and aromatase (CYP19) activity in human H295R adrenocortical carcinoma cells. Toxicol Appl Pharmacol 2005; 209:95–104. Li LA, Lin TC. Interacting influence of potassium and polychlorinated biphenyl on cortisol and aldosterone biosynthesis. Toxicol Appl Pharmacol 2007; 220:252–261. Li LA, Wang PW. PCB126 induces differential changes in androgen, cortisol and aldosterone biosynthesis in human adrenocortical H295R cells.

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