By Derek Leroith
Traditionally the sector of endocrine study has continuously been on the vanguard of clinical endeavors. The investigators of those vital breakthroughs in learn were rewarded by means of quite a few Nobel awards. within the box of diabetes by myself, Nobel prizes were provided to researchers who stumbled on insulin, characterised the protein and invented radioimmunoassays utilizing insulin as a paradigm. now not strangely, biomedical researchers have continuously been attracted by way of the endocrine method and different related platforms of intercellular communique. during the last 20 years, endocrine study has constructed swiftly and tailored sleek molecular and mobile biology strategies for its particular use. those alterations have allowed researchers within the box to take care of their side. hence, endocrine disease-related genes were characterised and mutations in those genes have helped clarify universal and no more universal endocrine problems. Our knowing of the legislation of gene expression has been significantly stronger by means of molecular concepts. In an try to deliver investigators modern with the hot advances during this exploding box we now have made up our minds to put up a chain entitled Advances in Molecular and mobile Endocrinology. across the world recognized investigators have agreed to take part and their contributions are liked. quantity 1 has interested in points of the hypothalamic-pituitary axis together with GnRH and GH gene rules, molecular features of insulin, insulin-like progress elements and glucagon. additionally, reports at the lately cloned calcium receptor and steroid receptor interactions with DNA are provided.
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Extra info for Advances in Molecular and Cellular Endocrinology, Volume 1
Mol. Endocrinol. 4, 476-480. , & Lee, E. (1992). Characterization, expression,, & estradiol regulation of the human GnRH gene. ), pp. 85-104. Springer-Verlag, New York. E. (1991). Migratory arrest of gonadotropin-releasing hormone neurons in transgenic mice. Proc. Natl. Acad. Sci. USA 88, 3402-3406. , Wray, S. E. (1994). Steroid hormone regulation and tissue-specific expression of the human GnRH gene in cell culture and transgenic animals. Horm. Behav. 28, 520-529. M. (1993). Role of nitric oxide in the control of luteinizing hormone-releasing hormone release in vivo and in vitro.
1992a) to investigate whether repression of GnRH mRNA by TPA was due to the activation of PKC, or to its subsequent downregulation. Treatment of GT1-7 cells with the inhibitor abolishes the induction of c-fos mRNA by TPA, but fails to antagonize the repression of GnRH mRNA. Instead, administration of the inhibitor alone causes a decrease in GnRH mRNA, indicating that TPA-repression of GnRH 18 M. CLARK, M. LAWSON, D. BELSHAM, S. ERALY,and P. MELLON is due to the downregulation of PKC. Thus, continued PKC activity is required for the maintenance of expression of the GnRH gene.
Steroid Biochem. Molec. Biol. 37, 899-902. D. (1990). Isolation and characterization of the human gonadotropin-releasing hormone gene in the hypothalamus and placenta. Mol. Endocrinol. 4, 476-480. , & Lee, E. (1992). Characterization, expression,, & estradiol regulation of the human GnRH gene. ), pp. 85-104. Springer-Verlag, New York. E. (1991). Migratory arrest of gonadotropin-releasing hormone neurons in transgenic mice. Proc. Natl. Acad. Sci. USA 88, 3402-3406. , Wray, S. E. (1994). Steroid hormone regulation and tissue-specific expression of the human GnRH gene in cell culture and transgenic animals.